RESEARCH INTERESTS

mTOR is a serine/threonine kinase that coordinates anabolic and catabolic processes in the cell as a response to extra cellular events such as nutrient levels, energy availability or stress situations. mTOR and its signalling pathways have been described mainly in proliferative non-neuronal cells. Therefore, the role that mTOR plays in differentiated cells as neurons is not very clear. There is evidence of mTOR as a modulator of survival, differentiation and development of neurons. It is also a key player in axonal growth, dendritic arborisation and synaptogenesis. In the adult brain, mTOR has been implicated in physiologic processes like neural plasticity, learning or memory. Moreover, its activity can be altered in pathological processes including tuberous sclerosis, Alzheimer's disease, Parkinson's disease, brain tumours and cortical dysplasia.

Our main research line is the study of mTOR and one of its main modulators, the protein RTP801, in neurodegeneration associated to Parkinson's disease, neural plasticity and development.

PUBLICATIONS

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